Endocrine Abstracts

Background: Neuroendocrine tumors (NETs) are unusual tumors with neural and secretory morphology and loss of Yes-associated protein (YAP). YAP is a transcriptional co-activator of the Hippo pathway and canonical oncogene in numerous cancers, except NETs. Although YAP typically binds TEAD transcription factors to drive gene expression, we demonstrate that YAP-TEAD complex formation represses NET differentiation and tumorigenesis through targeted gene dysregulation.<p class=...